Figure 10.
Changes in extracellular levels of potassium (K+), calcium (Ca2+), and H+ during spreading depression in the rat cerebellum measured using ion-selective microelectrodes; based on data by Charles Nicholson presented in Martins-Ferreira et al. (2000). Spreading depression was initiated by brief trains of local surface stimuli. Notice the biphasic change in extracellular levels of H+, with an initial small transient alkalinization followed by a larger and more prolonged extracellular acidification.