TABLE 3.
Mechanisms of CD24 involved in tumorigenesis due to glycosylation characteristics and different binding ligands
| The Role of CD24 in Cancer Development | |||
|---|---|---|---|
| Glycosylation Mediate Mechanisms | Ligand Mediated Mechanisms | ||
| Sialyl‐Lewis (x) promotes | Metastasis153 | P‐selectin | Metastasis153 |
| N‐acetylglucosamine | CSCs Self‐renewal and tumorigenicity154 | E‐selectin (CD62E) | Transfer and Scrolling155 |
|
L1 (CD171 or L1CAM) |
Progress and Proliferation156 | ||
|
Siglec‐G (mice) or Siglec−10 (humans) |
Immune Evasion99, 157 | ||
Abbreviation: L1CAM, L1 Cell Adhesion Molecule.