FIGURE 2.

Schematic diagram showed the time procedures for spinal nerve surgery and drug administration (A). Blockade effects of the β‐endorphin antiserum and μ‐opioid receptor (MOR) antagonist CTAP on IL‐10 mechanical antiallodynia and thermal antihyperalgesia in the ipsilateral hind paws (B), inhibition of spinal excitatory synaptic transmission (C‐E), and effects on inhibitory synaptic transmission (F‐H) in neuropathic rats. Neuropathic rats were induced by ligation of spinal nerves. Representative mEPSCs and mIPSCs traces, cumulative distribution and statistical analyses were obtained from the lamina II spinal dorsal horn neurons. The data are presented as the means ±SEM (n = 5–6 animals). *p < 0.05, by one‐way or repeated‐measures two‐way ANOVA followed by Sidak's post‐tests)