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. Author manuscript; available in PMC: 2022 Oct 15.
Published in final edited form as: Stat Med. 2021 Jun 21;40(23):5025–5045. doi: 10.1002/sim.9109

TABLE 1.

Different simulation scenarios

Scenario Type of pleiotropy Direct effects Confounder effects
1 Balanced 𝛿j ∼ ±N(0.7,0.22) 𝛼j = 0
2 Directional 𝛿j ∼ N(0.7,0.22) 𝛼j = 0
InSIDE satisfied
3 Directional 𝛿j ∼ N(0.7,0.22) 𝛼j ∼ N(0.4,0.22)
InSIDE violated