Skip to main content
. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: Immunity. 2021 Aug 2;54(9):1948–1960.e5. doi: 10.1016/j.immuni.2021.07.001

Figure 6. An ISR gene expression signature is evident in AdarP195A/p150− mice.

Figure 6.

(A-C) Expression data for ISR gene set genes in the liver, kidney, and cerebellum of 23 day old AdarP195A/p150− mice (n=7), plotting the log2 fold change over control AdarP195A/p150+ (n=5) mice. ISR genes that are not significantly changed are shown in bright red; significant expression changes are shown in dark red.

(D-F) Expression of ISR transcripts identified in the livers of rescued mice, measured by TaqMan qRT-PCR, and compared among the indicated genotypes. Each data point represents an individual mouse. AdarP195A/p150+ (n=6); AdarP195A/p150− (n=7); AdarP195A/p150+Ifihi1−/− (n=4); AdarP195A/p150−Ifih1−/− (n=6); AdarP195A/p150+Dhx58−/− (n=7); AdarP195A/p150−Dhx58−/− (n=8); AdarP195A/p150+Ifnar1−/− (n=4); AdarP195A/p150− Ifnar1−/− (n=7); AdarP195A/p150+Eif2ak2−/− (n=4); AdarP195A/p150−Eif2ak2−/− mice (n=4).