Fig. 6. Hi-C 3.0 detects both compartments and loops.
a, Distance-dependent contact probability of interactions detected with five protocols in HFFc6 cells (mean of trans interactions is shown in dashed lines). b, Derivative of the P(s) plots from a. c, Overlapping loops between FA + DSG–DdeI + DpnII and FA + DSG–MNase. d, Number of loops detected in 100-kb intervals (loop size) starting at 70 kb. e, Loop enrichment of 1,000 loops sampled from 100-kb intervals in d. When less than 1,000 loops were available, loop strengths for available loops were used. f, A–A and B–B compartment strengths in cis and in trans derived from saddle plot analysis. g, Number of loops and compartment strength for five protocols applied to HFFc6 cells. h, Compartment strength compared with loop enrichment for 10,000 loops sampled from HFFc6 cells (2,000 loops were sampled from each protocol). i, Compartment strength for 12 protocols described in Fig. 1a is compared to loop enrichment of these protocols using 10,000 sampled loops (in h) using data from the same 12 protocols.