KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| CD68 | Biolegend | Cat# 137001 |
| GFP | Abcam | Cat# ab13970 |
| RFP | Abcam | Cat# ab62341 |
| Cardiac actin | Sigma | Cat# A9357 |
| α-actinin | Sigma | Cat# A5044 |
| Ki67 | Abcam | Cat# ab15580 |
| Paxillin | Abcam | Cat# ab32084 |
| Cx43 | Cell Signaling | Cat# 3512 |
| Pan-Cadherin | Cell Signaling | Cat# 4068 |
| Claudin I | Cell Signaling | Cat# 13255 |
| Desmoplakin I/II | Abcam | Cat# ab16434 |
| Itgb1/CD29 | BD | Cat# 562219 |
| Itgb2/CD18 | BD | Cat# 557437 |
| TRPV4 | Millipore | Cat# MABS466 |
| IGF1 | R&D systems | Cat# AF791 |
| CYR61 | R&D systems | Cat# AF4055 |
| CD34 | Abcam | Cat# ab8158 |
| MHCII-APC/Cy7 | Biolegend | Cat# 107627 |
| CCR2-BV421 | Biolegend | Cat# 150605 |
| CD45-PerCP/Cy5.5 | Biolegend | Cat# 103131 |
| CD64-PE/Cy7, -PE, -APC | Biolegend | Cat# 139305, 139303, 139313 |
| Ly6G-PE/Cy7 | Biolegend | Cat# 127617 |
| Ly6C-APC, -FITC | Biolegend | Cat# 128015, 128005 |
| CD31-APC | Biolegend | Cat# 102409 |
| MEFSK4-PE | Miltenyi | Cat# 130-120-166 |
| HCN4 | Fisher | Cat# PA5-111878 |
| Ly6G | BD | Cat# 551459 |
| FAK | Abcam | Cat# ab76496 |
| Bacterial and Virus Strains | ||
| none | ||
| Biological Samples | ||
| none | ||
| Chemicals, Peptides, and Recombinant Proteins | ||
| RGD peptides | Selleckchem | Cat# S8008 |
| GSK1016790A | Selleckchem | Cat# S8107 |
| GSK2193874 | Tocris | Cat# 5106 |
| Ionomycin | Sigma | Cat# I9657 |
| Microfil | Flow Tech Inc. | Cat# MV-122 |
| Biotinylated Tomato Lectin | Vector labs | Cat# B-1175 |
| Wheat Germ Agglutinin | Vector labs | Cat# RL-1022 |
| Critical Commercial Assays | ||
| none | ||
| Deposited Data | ||
| Raw RNA sequencing data | deposited in GEO at time of publication | |
| Raw microarray data | deposited in GEO at time of publication | |
| Experimental Models: Cell Lines | ||
| HL1 cells | ||
| Experimental Models: Organisms/Strains | ||
| Mouse: B6;129-Tnnt2tm2Mmto | CARD | CARD: 1585 |
| Mouse: B6;129-Siglec1<tm1(HBEGF)Mtka> | RIKEN BRC | RBRC04395 |
| Mouse: B6.129-Tg(Flt3-cre)#Ccb/Ieg | EMMA | EMMA: 17790 |
| Mouse: B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J | Jackson Laboratory | JAX: 007909 |
| Mouse: B6(C)-Ccr2tm1.1Cln/J | Jackson Laboratory | JAX: 027619 |
| Mouse: Tg(Trpv4-EGFP)MT43Gsat/Mmucd | Mutant Mouse Resource and Research Centers |
MMRRC: 032771-UCD |
| Mouse: B6.129(Cg)-Cx3cr1tm1Litt Ccr2tm2.1Ifc/JernJ | Jackson Laboratory | JAX: 032127 |
| Mouse: B6.129P2(SJL)-Myd88tm1.1Defr/J | Jackson Laboratory | JAX: 009088 |
| Mouse: C57BL/6J-Ticam1Lps2/J | Jackson Laboratory | JAX: 005037 |
| Mouse: B6J.Cg-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/MwarJ | Jackson Laboratory | JAX: 028865 |
| Oligonucleotides | ||
| IGF1 | IDT | Mm.PT.58.5811533 |
| HB-EGF | IDT | Mm.PT.58.10448014 |
| CYR61 | IDT | Mm.PT.58.10039559 |
| IL-1β | IDT | Mm.PT.58.41616450 |
| TNF | IDT | Mm.PT.58.12575861 |
| IL6 | IDT | Mm.PT.58.10005566 |
| IP10 | IDT | Mm.PT.58.43575827 |
| MX2 | IDT | Mm.PT.58.29837402 |
| NPPA | IDT | Mm.PT.58.12973594 |
| NPPB | IDT | Mm.PT.58.8584045 |
| MYH7 | IDT | Mm.PT.58.17465550 |
| Recombinant DNA | ||
| none | ||
| Software and Algorithms | ||
| Partek Genomics | ||
| START | Nelson et al., 2017 |
https://doi.org/10.1093/bioinformatics/btw624
|
| Graph Pad PRISM | ||
| ImageJ | Schneider et al., 2012 |
https://imagej.nih.gov/ij/
|
| ZEN 3.0 SR (black edition) | ||
| Zeiss 3DXMViewer | ||
| ORS Dragonfly | ||