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. 2021 Sep 3;12:668974. doi: 10.3389/fimmu.2021.668974

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Copyright © 2021 Chen, Tu, Zou, Zhu, Zhao and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NETs were produced by PMA stimulation and degradation of NETs by the IgAV plasma were performed in vitro. Plasma from onset and active IgAV patients had decreased abilities to degrade NETs. The results showed significantly lower ratios of degradation of NETS in onset and active groups (^###P < 0.001, ***P < 0.001). Although the remission group showed some improvement in of degradation ability, they did not return to normal levels when compared to the control group (^#P = 0.035). The ability to degrade NETs was not significantly different between the withdrawal and normal groups (P > 0.05).