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Effect of temperature on the activation and localization of the small GTPase RhoA in MKD. Switching cells of MKD patients from 37°C to 40°C leads to GGPP depletion affecting protein geranylgeranylation and causing ectopic activation of the small GTPase RhoA. Guanine nucleotide dissociation inhibitor (GDI), guanine nucleotide exchange factor (GEF), GTPase activating protein (GAP).
