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. 2021 Sep 3;8:728777. doi: 10.3389/fmolb.2021.728777

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Copyright © 2021 Cheung, Kim and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular functions of BET proteins in gene transcription in chromatin. Illustration of the molecular functions of BET proteins in regulation of gene transcription in chromatin, including (I) transcription factor recruitment, (II) transcription factor stability, (III) chromatin remodeling, (IV) transcriptional elongation through phosphorylation of RNA Pol-II Ser2, (V) chromatin insulator activity, (VI) super-enhancer assembly and condensates, (VII) DNA damage response and genome integrity, and (VIII) integration of gene transcription and splicing.