Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of TREM2 structure. The structure of TREM2 protein mainly includes the signal peptide, extracellular domain which contains an immunoglobulin domain and a short stalk sequence, transmembrane helix and cytoplasmic tail. The α-secretase such as ADAM10 and ADAM17 can cleave TREM2 protein at histidine 157~serine 158 and release sTREM2, then the resultant transmembrane segment undergoes further proteolytic cleavage by γ-secretase.
