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. 2021 Sep 3;8:654912. doi: 10.3389/fmed.2021.654912

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Copyright © 2021 Paquissi and Abensur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summarized effects of the Th17/IL-17 axis on intrinsic renal cells (black arrows), as found in several kidney disease models, and on immune cells (red arrows) potentially implicated in the induction of kidney damage in lupus nephritis. DC, dendritic cells; EMT, epithelial-mesenchymal transition; IL-1, Interleukin-1; IL-17, Interleukin-17; IL-6, Interleukin-6; Mo/mΦ, Monocytes/macrophages; PC, Plasma Cells; Tfh, follicular helper T cells; Th17, T helper lymphocytes, subtype 17; Treg, Regulatory T Cell.