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. 2021 Sep 3;12:692496. doi: 10.3389/fphys.2021.692496

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Copyright © 2021 Credi, Balducci, Munagala, Cianca, Bigiarini, de Vries, Loew, Pavone, Cerbai, Sartiani and Sacconi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dose–dependent effects of E-4031 on AP kinetics. (A) APA, (B) APD₃₀, (C) APD₅₀, and (D) APD₉₀ as a function of E-4031 dose.