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. 2021 Sep 3;12:706662. doi: 10.3389/fgene.2021.706662

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Copyright © 2021 Alanazi, Lockhart-Cairns, Cain, Jowitt, Weiss and Baldock.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural characterisation of LTBP4 N- and C-terminal regions using small angle X-ray scattering. (A) The experimental 1D scattering intensity I plotted as a function of q for (i) CWT, C1286S and C1186R, and (ii) NWT and C274G constructs used for analysis and modelling. (B) The IFT of I vs. q using GNOM, P(r) vs. r for wild type and mutants indicate the maximum dimensions in real space. (C) Guinier plot of the low q region for the (i) CWT, C1286S and C1186R and (ii) NWT and C274G showing linearity. (D) Five example ab initio models generated by DAMMIN are shown each for CWT (purple), C1286S (green) and C1186R (gold) and (E) C274G (orange). Models are shown to the same scale and the average end-to-end length is indicated for each construct.