Table 1.
Vaccine targets with mapped epitopes against S. aureus USA300_TCH1516 strain
| Sl. | Protein Name | Gene | UniProt | Pathway | VaxiJen value | Epitope | Structure |
|---|---|---|---|---|---|---|---|
| 1 | Cell division protein DivIB | divIB | Q2FZ91 | Sax04112 Sulfur relay system | 0.70 | NNHVSTSKI | No |
| 2 | Hypothetical protein | – | Q2G0R4 | Unknown | 0.68 | RDDYYLSNKGE | No |
| 3 | Penicillin-binding protein 1 | pbpA | Q2FZ94 |
Sax00550 Peptidoglycan biosynthesis Sax01100 Metabolic pathways Sax01501 β-Lactam resistance |
0.63 | KMKSWYERFGFGKS | No |
| 4 | Penicillin-binding protein 2 | pbp2 | Q2FYI0 |
Sax00550 Peptidoglycan biosynthesis Sax01100 Metabolic pathways Sax01501 β-Lactam resistance |
0.58 | SSYQVDGSTFRNYDTK | 3DWK |
| 5 | Lipoteichoic acid synthase | ltaS | Q2FIS2 |
Sax00561 Glycerolipid metabolism Sax01100 Metabolic pathways |
0.50 | KTFWNRDQVYKHFG | 2W5Q |
| 6 | Phosphoglucomutase | pgcA | Q2FE11 |
Sax00010 Glycolysis/Gluconeogenesis Sax00030 Pentose phosphate pathway Sax00230 Purine metabolism Sax00500 Starch and sucrose metabolism Sax01100 Metabolic pathways Sax01110 Biosynthesis of secondary metabolites |
0.47 | FSSVQSANPEDHRAFD | No |
| 7 | Cell division protein FtsL | ftsL | Q2FZ95 | Unknown | 0.75 | IDKQSSENSA | No |
Seven extracellular proteins are selected for epitope prediction after checking their antigenicity