Table 2.
Predicted drug targets against S. aureus USA300_TCH1516 strain
| Sl No. | UniProt | Protein name | Sl No. | UniProt | Protein name |
|---|---|---|---|---|---|
| 1 | A8Z2L6 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit β (accD) | 28 | Q2FYI0 | Penicillin-binding protein 2 (pbp2) |
| 2 | Q2G268 | Coenzyme A biosynthesis bifunctional protein (coaBC) | 29 | Q2G2Q2 | Riboflavin biosynthesis protein |
| 3 | Q2FZY5 | Cysteine desulfurase | 30 | A8YZN7 | 50S ribosomal protein L10 (rplJ) |
| 4 | A8Z4Y6 | D-alanine–D-alanine ligase (ddl) | 31 | Q2FEP6 | 50S ribosomal protein L16 (rplP) |
| 5 | Q93QD4 | Malonyl CoA-acyl carrier protein transacylase FabD (fabD) | 32 | Q2FEP4 | 50S ribosomal protein L22 (rplV) |
| 6 | A8Z088 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 FabH (fabH) | 33 | Q2FER5 | DNA-directed RNA polymerase subunit alpha (rpoA) |
| 7 | Q6GI75 | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (fabI) | 34 | A8YZP0 | DNA-directed RNA polymerase subunit β (rpoB) |
| 8 | A8Z536 | Isopentenyl-diphosphate delta-isomerase Fni (fni) | 35 | Q2FEP5 | 30S ribosomal protein S3 (rpsC) |
| 9 | Q2G0Q5 | 2-amino-4-hydroxy-6-hydroxymethyl-dihydro pteridine pyrophosphokinase | 36 | Q2FEN8 | 30S ribosomal protein S10 (rpsJ) |
| 10 | Q2G0Q7 | Dihydropteroate synthase | 37 | A8Z333 | 30S ribosomal protein S13 (rpsM) |
| 11 | Q2FXR9 | Dihydrofolate synthase (folC) | 38 | P0A0J0 | RNA polymerase sigma factor SigA (sigA) |
| 12 | P0A040 | Glutamine synthetase (glnA) | 39 | Q2FZY7 | Fe-S cluster assembly ATPase SufC (sufC) |
| 13 | A8Z4T2 | 60 kDa chaperonin GroEL (groL) | 40 | Q2FJ01 | Teichoic acids export ATP-binding protein TagH (tagH) |
| 14 | Q5HJZ0 | DNA gyrase subunit A (gyrA) | 41 | Q2G041 | Thioredoxin-disulfide reductase |
| 15 | Q2FYG6 | Heptaprenyl diphosphate syntase component II | 42 | P0A017 | Dihydrofolate reductase (folA) |
| 16 | A8Z012 | UDP-N-acetylenolpyruvoylglucosamine reductase (murB) | 43 | Q2FIB3 | Glucose-6-phosphate isomerase (pgi) |
| 17 | A8Z4D3 | Nicotinate-nucleotide adenylyltransferase (nadD) | 44 | A8YZP4 | 30S ribosomal protein S7 (rpsG) |
| 18 | A8Z2S7 | Ammonia-dependent NAD (+) synthetase (nadE) | 45 | A8Z1J1 | D-alanine–D-alanyl carrier protein ligase (dltA) |
| 19 | Q2G078 | Ribonucleoside-diphosphate reductase subunit alpha (nrdA) | 46 | Q2FY51 | Dihydrolipoyl dehydrogenase |
| 20 | Q2G077 | Ribonucleoside-diphosphate reductase subunit β (nrdF) | 47 | Q2FXN4 | NADP-dependent isocitrate dehydrogenase |
| 21 | A8Z002 | Ribonucleotide-diphosphate reductase subunit gamma (nrdI) | 48 | Q2FE05 | UTP–glucose-1-phosphate uridylyltransferase (gtaB) |
| 22 | Q2G0W2 | NADH dehydrogenase subunit 5 | 49 | P64126 | Ferrochelatase (cpfC) |
| 23 | Q2FYS4 | DNA topoisomerase IV subunit A (parC) | 50 | Q2FE11 | Phosphogluco mutase (pgcA) |
| 24 | P0C1S7 | DNA topoisomerase IV subunit B (parE) | 51 | A8Z2N6 | 30S ribosomal protein S4 (rpsD) |
| 25 | Q2FZ94 | Penicillin-binding protein 1 (pbpA) | 52 | A8Z343 | 30S ribosomal protein S8 (rpsH) |
| 26 | A8Z1R9 | Phenylalanine–tRNA ligase subunit alpha (pheS) | 53 | A8Z344 | 30S ribosomal protein S14 type Z (rpsZ) |
| 27 | Q2FHU2 | Phenylalanine–tRNA ligasesubunit β (pheT) |
Essential non-homologous proteins are introduced to the DrugBank database search whether FDA-approved drugs are available for which the experimental evidence of binding with proteins similar to the target proteins