Table 1.
Clinical, demographic, and neuropsychological features in MSA patient with and without OH at baseline.
|
MSA with OH at T0
median (IQR) (N = 15) |
MSA without OH at T0
median (IQR) (N = 17) |
p | |
|---|---|---|---|
| Clinical and demographic variables | |||
| Age | 58 (9) | 62 (10) | 0.96 |
| Education | 11 (11) | 8 (4) | 0.09 |
| Disease duration | 3 (3) | 5 (2) | 0.48 |
| UMSARS-II | 20 (7) | 19 (16) | 0.96 |
| LEDD | 375 (164) | 304 (199) | 0.60 |
|
MSA with OH at T0% (N= 15) |
MSA without OH at T0% (N= 17) |
||
| Gender (M %) | 47% | 47% | 0.63 |
| Supine hypertension (%) | 18% | 0% | 0.22 |
| Urinary incontinence (%) | 80% | 88% | 0.65 |
| Neuropsychological variables | |||
| General cognition | |||
| - MOCA | 21 (8) | 21 (7) | 0.07 |
| Memory domain | |||
| −15-RAWLT-recalla | 7 (2) | 7 (7) | 0.39 |
| - Prose memorya | 12 (4) | 10 (4) | 0.66 |
| - Recall of Rey Osterrieth figurea | 10 (10) | 15 (14) | 0.84 |
| Attention domain | |||
| - TMT-Aa | 81 (48) | 64 (88) | 0.32 |
| - Stroop test-error interferencea | 2 (3) | 12 (18) | 0.04 |
| Executive domain | |||
| - CDTa | 9 (2) | 10 (3) | 0.19 |
| - Verbal fluency testa | 21 (17) | 18 (23) | 0.47 |
| - Copy of the Rey Osterrieth figurea | 28 (10) | 33 (16) | 0.52 |
| Visuospatial domain | |||
| - Constructional apraxia testa | 11 (5) | 11 (5) | 0.48 |
| - BJLOa | 18 (8) | 19 (11) | 0.55 |
| Language domain | |||
| - Picture naming totala | 12 (4) | 13 (2) | 0.98 |
| - Words/no-words repetition-totala | 8 (2)b | 7 (2)b | 0.02 |
| - Semantic associationa | 4 (1) | 4 (1) | 0.12 |
| Mood domain | |||
| - BDI-II | 13 (11) | 15 (19) | 0.95 |
| - AES | 33 (12) | 36 (15) | 0.20 |
| Functional autonomy | |||
| - ADL | 5 (2) | 6 (4) | 0.84 |
| - IADLa | 4 (2) | 6 (4) | 0.86 |
Statistically significant differences are indicated in bold.
MSA with OH vs. MSA without OH (corrected p ≤ 0.03).
15-RAWLT, Rey's auditory 15-word learning test; ADL, Basic Activities of Daily Life; AES, Apathy Evaluation Scale; BDI-II, Beck Depression Inventory; BJLO, Benton's Judgment of Line Orientation; CDT, Clock Drawing test; IADL, Instrumental Activities of Daily Life; IQR, interquartile range; LEDD, total L-dopa equivalent daily dose; M, male; MCI, mild cognitive impairment; MOCA, Montreal Cognitive Assessment battery; MSA, multiple system atrophy; OH, orthostatic hypotension; N, number; NC, normal cognition; p, p-value; TMT-A, part A of Trail Making Test; T0, baseline; UMSARS, Unified Multiple System Atrophy Rating Scale.