Table 3.

Changes in neuropsychological tests between MSA patients with and without OH at T₂.

	MSA with OH median (IQR) (N = 7)	MSA without OH median (IQR) (N = 6)	p
Delta T 2 – T 0
General cognition
- MOCA	−1 (5)	−4 (6)	0.66
Memory domain
−15-RAWLT-recalla	1 (3)	−3 (7)	0.16
- Prose memorya	−1 (8)	0 (6)	0.86
- Recall of Rey Osterrieth figurea	−1 (3)	−4 (7)	0.17
Attention domain
- TMT-Aa	24 (26)	10 (39)	0.36
- Stroop test-error interferencea	−1 (4)	−28 (29)	0.04
Executive domain
- CDTa	−2 (9)	−1 (4)	0.90
- Verbal fluency testa	−5 (14)	−3 (8)	0.93
- Copy of the Rey Osterrieth figurea	−7 (10)	−8 (19)	0.46
Visuospatial domain
- Constructional apraxia testa	−2 (6)	−3 (3)	0.52
- BJLOa	−4 (7)	−4 (2)	0.92
Language domain
- Picture Naming totala	0 (3)	−1 (3)	0.81
- Words/no-words repetition-totala	0 (0)	1 (0)	0.11
− Semantic associationa	−1 (2)	0 (0)	0.32
Mood domain
- BDI-II	−4 (15)	−5 (6)	0.46
- AES	4 (36)	−5 (45)	0.48
Functional autonomy
- ADL	−2 (1)	−2 (2)	0.62
- IADLa	−2 (3)	−1 (3)	0.64

Statistically significant differences are indicated in bold.

^aTests used to identify NC, MCI, and dementia (16, 19).

15-RAWLT, Rey's auditory 15-word learning test; ADL, Basic Activities of Daily Life; AES, Apathy Evaluation Scale; BDI-II, Beck Depression Inventory; BJLO, Benton's Judgment of Line Orientation; CDT, Clock Drawing test; IADL, Instrumental Activities of Daily Life; IQR, interquartile range; MCI, mild cognitive impairment; MOCA, Montreal Cognitive Assessment battery; MSA, multiple system atrophy; OH, orthostatic hypotension; N, number; NC, normal cognition; p, p-value; TMT-A, part A of Trail Making Test; T₀, baseline; T₂, follow up 2.