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. 2021 Sep 3;12:715693. doi: 10.3389/fphys.2021.715693

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Copyright © 2021 Prem and Kurian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal physiology and biochemistry analysis of ND and HD rats subjected to IR (A) kidney to body weight ratio, (B) eGFR, (C) plasma creatinine, (D) plasma BUN, (E) urinary albumin/creatinine ratio, and (F) renal injury score from (H,E) staining. *p < 0.05 vs. ND, ^#p < 0.05 vs. ND-IR. The data are presented as mean ± SD (n = 6/group). H&E stained images for ND and HD renal tissue subjected to IR injury (G) ND, (H) ND-IR, (I) HD, and (J) HD-IR (n = 3/group). The images are presented at 10x magnification. *Indicates tubular cast formation, arrow indicates extensive tubular dilatation, and arrow head indicates tubular necrosis. ND, Normal diet fed; FD, High fat diet fed; IR, Ischemia-reperfusion.