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. 2021 Sep 3;12:737083. doi: 10.3389/fimmu.2021.737083

Figure 1.

Figure 1

mRNA-1273 vaccination induces different pattern of WT RBD-specific IgG subclass responses in SARS-CoV-2 naïve and recovered individuals. (A) Schematic diagram of the cohort characteristics. M, male. F, female. (B) Schematic diagram of the study timeline. Sera were collected at 3 time points: pre-vaccine baseline, 2/3 weeks post the first dose (PFD) and 1 month post the second dose (PSD). Range of days per time point is indicated with a box. (C) Area under the curve (AUC) for each of the WT RBD-specific IgG subclasses analyzed from SARS-CoV-2 naïve individuals overtime. (D) AUC for each of the WT RBD-specific IgG subclasses analyzed from SARS-CoV-2 recovered individuals overtime. (E) AUC for each of the WT RBD-specific IgG subclasses analyzed from SARS-CoV-2 naïve and recovered individuals overtime depicted in the same graph. Sera from SARS-CoV-2 naïve individuals at baseline were used to establish negative threshold values defined as the naïve AUC mean plus 2 times the standard deviation of the mean. Bars represent mean ± standard error mean (SEM). Dashed line indicates negative threshold. Data are presented as individual dots. Wilcoxon matched pairs test was performed to compare time points. Two-tailed Mann-Whitney U test was performed to compare SARS-CoV-2 naïve and recovered individuals (ns, not significant P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001). SARS-CoV-2 naïve, n=27; SARS CoV-2 recovered, n=19.