TABLE 1.

Sex- and age-specific rates of Alzheimer’s disease and other forms of dementia in China in 1990 and in 2019 and their average annual percentage changes (AAPC) from 1990 to 2019.

Categories	Males			Females			Overall
	Rates in 1990 (95% UI)	Rates in 2019 (95% UI)	AAPC,% (95%CI)	Rates in 1990 (95% UI)	Rates in 2019 (95% UI)	AAPC,% (95%CI)	Rates in 1990 (95% UI)	Rates in 2019 (95% UI)	AAPC,% (95%CI)
Incidence
40–44 years	4.4 (2.17–7.17)	4.47 (2.21–7.41)	0.15 (0.1–0.21)*	4.81 (2.41–7.88)	4.9 (2.44–8.04)	0.17 (0.13–0.22)*	4.6 (2.3–7.51)	4.68 (2.33–7.74)	0.17 (0.12–0.22)*
45–49 years	17.58 (11.13–25.19)	19.29 (12.1–27.99)	0.38 (0.34–0.42)*	19.64 (12.34–27.98)	21.47 (13.39–30.69)	0.35 (0.32–0.38)*	18.55 (11.73–26.53)	20.36 (12.79–29.2)	0.37 (0.34–0.4)*
50–54 years	35.18 (22.86–49.69)	42.29 (27.15–59.73)	0.65 (0.58–0.72)*	39.37 (25.41–55.6)	47.04 (30.09–66.58)	0.6 (0.53–0.67)*	37.15 (24.03–52.58)	44.65 (28.6–62.87)	0.64 (0.57–0.7)*
55–59 years	64.04 (43.27–90.34)	86.43 (57.57–119.97)	0.93 (0.87–0.99)*	73.08 (49.14–104.6)	94.84 (62.61–132.83)	0.8 (0.73–0.87)*	68.34 (46.28–96.57)	90.61 (60.17–126.33)	0.87 (0.81–0.93)*
60–64 years	106.8 (71.1–152.09)	148.13 (100.28–208.36)	0.88 (0.77–0.99)*	131.67 (87.24–189.54)	173.72 (115.92–248.25)	0.73 (0.63–0.82)*	118.86 (79.14–170.37)	160.87 (108.68–227.79)	0.81 (0.71–0.91)*
65–69 years	176.12 (116.84–262.57)	231.6 (153.89–342.54)	0.67 (0.56–0.79)*	238.62 (158.94–350.82)	324.07 (215.29–475.56)	0.68 (0.54–0.83)*	207.89 (138.05–307.74)	278.68 (186.29–409.52)	0.68 (0.55–0.81)*
70–74 years	345.55 (220.42–502.82)	440.18 (284.4–629.21)	0.62 (0.52–0.71)*	492.84 (317.19–709.63)	677.82 (451.69–960.68)	0.7 (0.56–0.85)*	424.54 (271.67–613.67)	561.98 (371.91–792.98)	0.63 (0.51–0.76)*
75–79 years	766.12 (522.34–1083.1)	954.76 (652.41–1346.14)	0.62 (0.54–0.69)*	1113.24 (760.84–1551.69)	1384.98 (956.7–1916.07)	0.47 (0.36–0.57)*	963.86 (656.88–1350.07)	1181.21 (813.66–1639.01)	0.45 (0.36–0.55)*
80–84 years	1384.36 (931.63–1918.8)	1630.32 (1107.75–2264.72)	0.51 (0.45–0.57)*	1952.14 (1325.67–2657.22)	2099.37 (1433.16–2922.43)	0.16 (0.1–0.21)*	1733.09 (1172.66–2374.03)	1893.35 (1287.45–2619.85)	0.22 (0.17–0.28)*
85–89 years	2108.97 (1467.06–2894.39)	2360.38 (1661.81–3252.72)	0.34 (0.27–0.41)*	2760.42 (1949.81–3779.14)	2735.93 (1913.04–3797.69)	−0.05 (–0.11–0.01)	2557.18 (1797.05–3500.72)	2604.45 (1825.1–3610.72)	0.04 (–0.02–0.11)
Age-standardized rate	75.14 (62.9–86.73)	89.65 (74.93–103.22)	0.49 (0.43–0.55)*	100.28 (84.67–115.63)	115.24 (97.62–132.73)	0.31 (0.24–0.38)*	90.44 (76.25–104.07)	103.83 (87.93–118.87)	0.33 (0.27–0.4)*
Mortality
40–44 years	0.12 (0.01–0.43)	0.11 (0.01–0.37)	−0.29 (−0.42–0.15)*	0.12 (0.01–0.44)	0.1 (0.01–0.36)	−0.55 (−0.67–0.44)*	0.12 (0.01–0.43)	0.1 (0.01–0.36)	−0.5 (−0.6–0.39)*
45–49 years	0.81 (0.11–2.74)	0.71 (0.09–2.33)	−0.42 (−0.5–0.35)*	0.88 (0.12–2.87)	0.73 (0.09–2.48)	−0.68 (−0.77–0.6)*	0.84 (0.11–2.79)	0.72 (0.09–2.32)	−0.55 (−0.62–0.48)*
50–54 years	2.22 (0.37–7.28)	1.95 (0.31–6.05)	−0.37 (−0.48–0.26)*	2.51 (0.41–7.84)	2.12 (0.33–6.71)	−0.51 (−0.6–0.41)*	2.36 (0.39–7.53)	2.03 (0.32–6.27)	−0.43 (−0.53–0.33)*
55–59 years	5.57 (1.01–16.72)	5.12 (0.94–15.34)	−0.11 (−0.25–0.03)	6.4 (1.17–17.97)	5.91 (1.06–17.38)	−0.01 (−0.17–0.14)	5.96 (1.11–17.19)	5.51 (1.01–16.26)	−0.05 (−0.19–0.09)
60–64 years	12.21 (2.58–34.78)	12.03 (2.44–36.82)	0.19 (0.05–0.33)*	14.52 (3.03–42.1)	14.51 (3.01–42.33)	0.29 (0.15–0.42)*	13.33 (2.93–39.45)	13.26 (2.72–40.37)	0.25 (0.12–0.39)*
65–69 years	24.56 (5.35–72.57)	24.41 (5.23–73.23)	0.24 (0.11–0.38)*	30.21 (6.48–89.18)	29.93 (6.43–85.55)	0.26 (0.14–0.38)*	27.43 (6.06–81.42)	27.22 (5.96–80.84)	0.25 (0.13–0.38)*
70–74 years	48.8 (10.7–144.28)	49.35 (10.88–140.16)	0.27 (0.14–0.4)*	62.66 (13.6–177.5)	61.76 (13.74–170.1)	0.2 (0.1–0.29)*	56.23 (12.39–164.79)	55.71 (12.51–160.23)	0.2 (0.1–0.31)*
75–79 years	107.26 (23.73–327.9)	110.28 (24.38–333.83)	0.33 (0.2–0.47)*	146.3 (32.03–423.93)	141.99 (32.6–407.45)	0.14 (0.04–0.25)*	129.5 (28.39–378.68)	126.97 (28.86–358.84)	0.17 (0.06–0.28)*
80–84 years	336.86 (75.54–993.17)	351.28 (78.21–1054)	0.33 (0.21–0.45)*	471.38 (105.65–1379.28)	451.76 (105.36–1245.61)	0.01 (–0.08–0.09)	419.48 (93.81–1253.74)	407.63 (93.39–1133.43)	0.06 (–0.03–0.16)
85–89 years	780.42 (175.7–2264.23)	826.57 (188.84–2375.66)	0.37 (0.27–0.47)*	1062.62 (248.35–2937.88)	1015.43 (238.27–2611.08)	−0.1 (−0.15–0.04)*	974.58 (227.25–2679.16)	949.31 (220.72–2514.2)	0.01 (−0.06–0.08)
Age-standardized rate	19.07 (4.35–53.18)	20.25 (4.8–57.38)	0.42 (0.31–0.53)*	25.42 (5.97–69.18)	24.92 (5.98–64.47)	0.08 (0–0.15)	23.41 (5.4–64.04)	23.32 (5.66–61.31)	0.15 (0.07–0.23)*

^∗Changes that are statistically significant.