TABLE 2.

Sex-specific relative risks of the incidence of and mortality due to Alzheimer’s disease and other forms of dementia in China due to age, period, and cohort effects.

Factor	Incidence in males		Incidence in females		Mortality in males		Mortality in females
	RR (95% CI)	P-value	RR (95% CI)	P-value	RR (95% CI)	P-value	RR (95% CI)	P-value
Age
40–44	0.08 (0.06–0.11)	<0.001	0.07 (0.05–0.10)	<0.001	0.03 (0.00–0.27)	0.002	0.03 (0.00–0.24)	0.001
45–49	0.28 (0.24–0.34)	<0.001	0.26 (0.22–0.31)	<0.001	0.19 (0.08–0.47)	<0.001	0.18 (0.07–0.42)	<0.001
50–54	0.53 (0.46–0.61)	<0.001	0.48 (0.42–0.55)	<0.001	0.44 (0.22–0.87)	0.019	0.42 (0.22–0.81)	0.01
55–59	0.95 (0.85–1.06)	0.398	0.85 (0.77–0.95)	0.003	0.97 (0.58–1.64)	0.915	0.96 (0.58–1.58)	0.857
60–64	1.53 (1.40–1.67)	<0.001	1.45 (1.34–1.58)	<0.001	1.89 (1.26–2.84)	0.002	1.93 (1.30–2.85)	0.001
65–69	2.20 (2.05–2.37)	<0.001	2.45 (2.29–2.61)	<0.001	3.27 (2.36–4.54)	<0.001	3.42 (2.49–4.68)	<0.001
70–74	3.72 (3.50–3.95)	<0.001	4.48 (4.24–4.73)	<0.001	5.65 (4.25–7.52)	<0.001	6.07 (4.60–8.00)	<0.001
75–79	7.15 (6.75–7.59)	<0.001	8.26 (7.82–8.72)	<0.001	10.94 (8.17–14.65)	<0.001	12.13 (9.12–16.13)	<0.001
Period
1994	0.70 (0.65–0.76)	<0.001	0.70 (0.65–0.75)	<0.001	0.67 (0.48–0.93)	0.017	0.67 (0.49–0.92)	0.012
1999	0.82 (0.77–0.86)	<0.001	0.81 (0.77–0.85)	<0.001	0.78 (0.62–0.98)	0.03	0.78 (0.63–0.96)	0.02
2004	0.93 (0.89–0.98)	0.006	0.93 (0.89–0.97)	<0.001	0.97 (0.83–1.14)	0.714	0.95 (0.83–1.10)	0.498
2009	1.06 (1.01–1.11)	0.027	1.05 (1.01–1.10)	0.019	1.12 (0.96–1.31)	0.158	1.13 (0.98–1.31)	0.101
2014	1.25 (1.18–1.32)	<0.001	1.26 (1.20–1.32)	<0.001	1.23 (0.99–1.54)	0.067	1.25 (1.01–1.54)	0.039
2019	1.41 (1.32–1.51)	<0.001	1.44 (1.36–1.53)	<0.001	1.43 (1.05–1.93)	0.021	1.43 (1.07–1.92)	0.015
Cohort
1915–1919	1.96 (1.75–2.20)	<0.001	2.11 (1.90–2.34)	<0.001	2.37 (1.37–4.12)	0.002	2.49 (1.46–4.27)	0.001
1920–1924	1.77 (1.61–1.94)	<0.001	1.84 (1.69–2.01)	<0.001	2.08 (1.28–3.37)	0.003	2.15 (1.34–3.47)	0.002
1925–1929	1.56 (1.43–1.71)	<0.001	1.61 (1.49–1.75)	<0.001	1.82 (1.16–2.86)	0.01	1.86 (1.18–2.91)	0.007
1930–1934	1.39 (1.27–1.51)	<0.001	1.41 (1.31–1.53)	<0.001	1.60 (1.01–2.53)	0.043	1.60 (1.02–2.52)	0.042
1935–1939	1.24 (1.13–1.36)	<0.001	1.25 (1.15–1.36)	<0.001	1.39 (0.85–2.25)	0.186	1.39 (0.86–2.25)	0.183
1940–1944	1.12 (1.02–1.23)	0.023	1.12 (1.02–1.22)	0.013	1.21 (0.71–2.05)	0.488	1.21 (0.71–2.04)	0.483
1945–1949	1.00 (0.89–1.120)	0.998	1.00 (0.90–1.12)	0.962	1.05 (0.57–1.93)	0.88	1.05 (0.58–1.93)	0.865
1950–1954	0.89 (0.78–1.03)	0.115	0.88 (0.78–1.01)	0.061	0.89 (0.44–1.82)	0.754	0.90 (0.45–1.82)	0.776
1955–1959	0.81 (0.69–0.96)	0.013	0.79 (0.68–0.93)	0.004	0.76 (0.33–1.74)	0.508	0.76 (0.34–1.72)	0.515
1960–1964	0.74 (0.61–0.90)	0.003	0.72 (0.60–0.87)	0.001	0.63 (0.23–1.71)	0.362	0.63 (0.24–1.67)	0.35
1965–1969	0.66 (0.51–0.84)	0.001	0.64 (0.51–0.81)	<0.001	0.53 (0.15–1.91)	0.332	0.52 (0.15–1.81)	0.302
1970–1974	0.57 (0.40–0.80)	0.001	0.54 (0.39–0.75)	<0.001	0.45 (0.07–2.97)	0.407	0.43 (0.07–2.77)	0.376
1975–1979	0.48 (0.19–1.19)	0.111	0.46 (0.19–1.09)	0.077	0.39 (0.00–141.49)	0.756	0.37 (0.00–135.78)	0.739
Deviance	0.61		0.54		0.03		0.07
AIC	7.3		7.5		4.78		4.93
BIC	−92.29		−92.37		−92.88		−92.84

RR denotes the relative risk of the incidence and mortality in a particular age, period, or birth cohort relative to the average level of all ages, periods, or birth cohorts combined. RR, relative risk; CI, confidence interval; AIC, Akaike Information Criterion; BIC, Bayesian Information Criterion.