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. 2021 Sep 3;13:722580. doi: 10.3389/fnagi.2021.722580

FIGURE 2.

FIGURE 2

PDE4D deficiency improved cognition and memory in the novel object recognition test in Aβ1–42-treated mice. The discrimination index 3 h (A) and 24 h (B) after the training session was recorded after microinjection of lenti-PDE4D-miRNA into the prefrontal cortex for 2 weeks. In the open field test, the total distance traveled did not shown a change after PDE4D deficiency. (C) Values were the means ± SEM with 12 mice in each group. *P < 0.05, **P < 0.01 vs. control group (NC); #P < 0.05, ##P < 0.01 vs. Aβ+Veh group; $P < 0.05 vs. Aβ+4DmiRNA group.