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PDE4D deficiency increased expression of PKA (A), p-CREB (B), BDNF (C), Bcl-2/Bax (D), and decreased caspase-3 (E) level in Aβ1–42-treated mice. Results are expressed as mean ± SEM (n = 12). *P < 0.05, **P < 0.01 vs. control group (NC); #P < 0.05 vs. Aβ+Veh group; $P < 0.05 vs. Aβ+4DmiRNA group.
