TABLE 2.

Univariate and multivariate Cox regression analysis of clinical information and RS

Univariate Cox regression analysis			Multivariate Cox regression analysis
Training dataset
Risk factors	HR (95%CI)	p value	Risk factors	HR (95%CI)	p value
Gender (male vs. female)	0.90(0.65–1.27)	0.559	Gender (male vs. female)	1.07(0.75–1.52)	0.716
Age (≥60 vs. <60)	1.24(0.88–1.74)	0.217	Age (≥60 vs. <60)	2.10(1.46–3.00)	<0.001
Stage	3.41(2.34–4.96)	<0.001	Stage	1.32(0.89–1.96)	0.175
RS	2.72(2.15–3.44)	<0.001	RS	2.76(2.13–3.58)	<0.001
Validation dataset I
Risk factors	HR (95%CI)	p value	Risk factors	HR (95%CI)	p value
Gender (male vs. female)	1.4(0.91–2.17)	0.127	Gender (male vs. female)	0.76(0.48–1.21)	0.542
Age (≥60 vs. <60)	0.98(0.64–1.51)	0.936	Age (≥60 vs. <60)	1.02(1.00–1.03)	0.07
Stage	2.79(2.14–3.64)	<0.001	Stage	3.07(2.31–4.07)	<0.001
RS	1.39(1.08–1.79)	0.011	RS	1.58(1.21–2.08)	<0.001
Validation dataset II
Risk factors	HR (95%CI)	p value	Risk factors	HR (95%CI)	p value
Gender (male vs. female)	1.26(0.93–1.70)	0.141	Gender (male vs. female)	1.24(0.91–1.67)	0.171
Age (≥60 vs. <60)	1.79(2.34–2.39)	<0.001	Age (≥60 vs. <60)	1.94(1.45–2.61)	<0.001
RS	1.54(1.14–2.07)	0.005	RS	1.72 (1.27–2.33)	<0.001