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. 2021 Jul 26;10(18):6416–6427. doi: 10.1002/cam4.4159

FIGURE 5.

FIGURE 5

DYRK1A regulated NFATC1 to facilitate glioma cell migration. A, T98G cells were transfected with DYRK1A and NFATC1 expression vectors alone or simultaneously. Transwell assay showed that co‐expression of DYRK1A and NFATC1 greatly increased T98G cell migration. B, T98G cells were transfected with vectors knocking down DYRK1A and/or NFATC1. Simultaneous knockdown of DYRK1A and NFATC1 decreased T98G cell migration. C, T98G cells were transfected with DYRK1A or NFATC1 mutant expression vector alone or simultaneously. Transwell assay showed that co‐expression of DYRK1A and NFATC1 mutants marginally increased T98G cell migration. D, MTT assay showed that T98G cell viability was not affected by expression levels of DYRK1A and/or NFATC1. E, MTT assay showed that T98G cell viability was not affected by knockdown of DYRK1A and/or NFATC1. F, MTT assay showed that T98G cell viability was not affected by expression of DYRK1A and/or NFATC1 mutants. Values represent means ± SD, n = 3