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Metabolism in M1 and M2 macrophages. M1 macrophages display an enhanced glycolysis, PPP, FA synthesis, a decreased OXPHOS, and TCA cycle. Activation of glycolysis which results in increased production of lactate, increased FA uptake and synthesis, and increased uptake of glutamine to fuel the TCA cycle. M2 cells are well known as anti‐inflammatory macrophages with enhanced OXPHOS and activated FAO, reduced glycolysis, and PPP
