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Regulation metabolism of T cells. (A) Activated T cells have increased metabolic processes to secrete activating cytokines such as IFN‐γ. However, tumor cells can have upregulation of alternate immune checkpoints to produce immune escape. (B) Fatty acids can increase the CPT gene expression causing increased ROS and CD4+ T‐cell death produce an immunosuppressive TME. (C) CTLA‐4 and PD‐1 immune checkpoints can alter T‐cell metabolism causing T‐cell anergy, exhaustion, and autophagy
