Figure 1.

Glycolysis in cancer: cancer cells choose glycolysis as their primary energy source even under normoxia, which means pyruvate is mainly converted into lactate to play its role in energy source, rather than being incorporated into the TCA cycle. GLUT1 is responsible for transporting glucose, and MCTs are responsible for transporting lactate. ②, phosphohexose isomerase; ④, aldolase; ⑤, triose phosphate isomerase; ⑥, glyceraldehyde 3-phosphate dehydrogenase; ⑦, phosphoglycerate kinase; ⑧, phosphoglycerate mutase; ⑨, enolase.