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. 2021 Sep 3;12:707267. doi: 10.3389/fimmu.2021.707267

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Copyright © 2021 Altaie, Venkatachalam, Samaranayake, Soliman and Hamoudi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative comparison of shared metabolites in periapical lesions and healthy control. The quantity of each metabolite was represented as the area under the peak of each metabolite in relation to the total areas of all other metabolites detected in an extract. The data displayed the fold change of area under the peak values of each metabolite in each group. The data were analyzed by two-way analysis of variance (ANOVA) using Tukey’s multiple comparisons test. P-value ≤ 0.05 was considered as significant. (A) Shared metabolites between periapical lesions and healthy control. Hexadecane in healthy control was regarded as one-fold and employed as a reference for the measurement of the other metabolites. (B) Shared metabolites between periapical lesions only. 2-Methylhexacosane in periapical abscess was used as a reference of one-fold for the measurement of metabolites in other lesions. **** reveals that P-value < 0.0001.