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. 2021 Sep 3;12:707267. doi: 10.3389/fimmu.2021.707267

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Copyright © 2021 Altaie, Venkatachalam, Samaranayake, Soliman and Hamoudi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative real-time PCR of selected genes identified in correlation to enriched pathways in periapical lesions compared with healthy control. Ten clinical samples in each group were investigated and each sample was replicated three times. The data display the fold change in gene expression between groups. The data were analyzed by one-way analysis of variance (ANOVA) using Tukey’s multiple comparisons test. P-value ≤0.05 was considered as significant. (A) CYP4F3. (B) VEGF. (C) MMP-9. (D) IL-8. (E) TLR2. (F) IL-17A. (G) TLR4. (H) IL-6. (I) IL-10. (J) IL-12A. * reveals that P-value < 0.05, ** reveals that P-value < 0.01, *** reveals that P-value < 0.001, **** reveals that P-value < 0.0001.