Table 1.
Clinical characteristics of the tissue samples involved in metabolomics and gene expression analyses.
| Sample | Sex | Age (years) | Tooth | Lesion/clinical characteristics | Experimental method |
|---|---|---|---|---|---|
| Healthy control 1 | Female | 28 | 48 | Completely impacted tooth | GC-MS |
| Healthy control 2 | Female | 28 | 18 | Completely impacted tooth | GC-MS |
| Healthy control 3 | Male | 65 | 48 | Completely impacted tooth | GC-MS |
| Healthy control 4 | Female | 31 | 48 | Completely impacted tooth | GC-MS |
| Healthy control 5 | Female | 22 | 48 | Completely impacted tooth | GC-MS |
| Healthy control 6 | Female | 28 | 18 | Completely impacted tooth | qRT-PCR |
| Healthy control 7 | Female | 28 | 48 | Completely impacted tooth | qRT-PCR |
| Healthy control 8 | Male | 60 | 48 | Completely impacted tooth | qRT-PCR |
| Healthy control 9 | Female | 31 | 48 | Completely impacted tooth | qRT-PCR |
| Healthy control 10 | Male | 24 | 48 | Completely impacted tooth | qRT-PCR |
| Healthy control 11 | Male | 20 | 38 | Completely impacted tooth | qRT-PCR |
| Healthy control 12 | Female | 22 | 38 | Completely impacted tooth | qRT-PCR |
| Healthy control 13 | Female | 35 | 28 | Completely impacted tooth | qRT-PCR |
| Healthy control 14 | Female | 22 | 48 | Completely impacted tooth | qRT-PCR |
| Healthy control 15 | Female | 28 | 38 | Completely impacted tooth | qRT-PCR |
| Periapical abscess 1 | Male | 66 | 37 | Swelling/pain/root resorption | GC-MS |
| Periapical abscess 2 | Male | 40 | 27 | Swelling/pain/slight root resorption | GC-MS |
| Periapical abscess 3 | Male | 35 | 36 | Swelling/pain/fever/root resorption | GC-MS |
| Periapical abscess 4 | Female | 54 | 15 | Swelling/pain/slight root resorption | GC-MS |
| Periapical abscess 5 | Female | 35 | 35 | Swelling/pain/slight root resorption | GC-MS |
| Periapical abscess 6 | Male | 25 | 25 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 7 | Male | 30 | 36 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 8 | Male | 40 | 27 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 9 | Male | 45 | 16 | Mild swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 10 | Male | 20 | 45 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 11 | Male | 24 | 46 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 12 | Male | 35 | 15 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 13 | Male | 27 | 17 | Swelling/pain/root resorption | qRT-PCR |
| Periapical abscess 14 | Male | 52 | 13 | Swelling/pain/slight root resorption | qRT-PCR |
| Periapical abscess 15 | Male | 34 | 46 | Swelling/pain/slight root resorption | qRT-PCR |
| Radicular cyst 1 | Male | 24 | 46 | ~3 mm/no root resorption | GC-MS |
| Radicular cyst 2 | Male | 35 | 46 | ~4 mm/no root resorption | GC-MS |
| Radicular cyst 3 | Female | 54 | 43 | ~4 mm/no root resorption | GC-MS |
| Radicular cyst 4 | Male | 25 | 28 | ~4 mm/slight root resorption | GC-MS |
| Radicular cyst 5 | Male | 25 | 28 | ~5 mm/root resorption | qRT-PCR |
| Radicular cyst 6 | Male | 24 | 46 | ~4 mm/no root resorption | qRT-PCR |
| Radicular cyst 7 | Male | 35 | 46 | ~3 mm/no root resorption | qRT-PCR |
| Radicular cyst 8 | Male | 54 | 44 | ~3 mm/no root resorption | qRT-PCR |
| Radicular cyst 9 | Male | 35 | 15 | ~4 mm/no root resorption | qRT-PCR |
| Radicular cyst 10 | Female | 36 | 17 | ~5 mm/slight root resorption | qRT-PCR |
| Radicular cyst 11 | Male | 32 | 35 | ~4 mm/slight root resorption | qRT-PCR |
| Radicular cyst 12 | Male | 33 | 27 | ~6 mm/slight root resorption | qRT-PCR |
| Radicular cyst 13 | Male | 49 | 46 | ~6 mm/slight root resorption | qRT-PCR |
| Radicular cyst 14 | Female | 20 | 46 | ~4 mm/slight root resorption | qRT-PCR |
| Periapical granuloma 1 | Male | 37 | 18 | ~5 mm/root resorption | GC-MS |
| Periapical granuloma 2 | Female | 20 | 15 | ~3 mm/slight root resorption | GC-MS |
| Periapical granuloma 3 | Male | 49 | 16 | ~6 mm/root resorption | GC-MS |
| Periapical granuloma 4 | Female | 33 | 47 | ~3 mm/slight root resorption | GC-MS |
| Periapical granuloma 5 | Male | 25 | 36 | ~5 mm/slight root resorption | qRT-PCR |
| Periapical granuloma 6 | Male | 42 | 25 | ~4 mm/root resorption | qRT-PCR |
| Periapical granuloma 7 | Male | 49 | 17 | ~4 mm/slight root resorption | qRT-PCR |
| Periapical granuloma 8 | Male | 37 | 18 | ~6 mm/root resorption | qRT-PCR |
| Periapical granuloma 9 | Male | 38 | 15 | ~4 mm/root resorption | qRT-PCR |
| Periapical granuloma 10 | Male | 21 | 16 | ~3 mm/root resorption | qRT-PCR |
| Periapical granuloma 11 | Female | 20 | 15 | ~5 mm/root resorption | qRT-PCR |
| Periapical granuloma 12 | Female | 35 | 25 | ~4 mm/root resorption | qRT-PCR |
| Periapical granuloma 13 | Male | 49 | 16 | ~7 mm/root resorption | qRT-PCR |
| Periapical granuloma 14 | Female | 33 | 47 | ~4 mm/slight root resorption | qRT-PCR |