Table 2.
The highest distribution of single nucleotide polymorphism in a population of gene-related enrichment pathways of periapical lesions in human genome assembly (GRCh38.p12).
| Gene | Accession number | Chromosome | Position | Reference SNP | Alleles | Population | Alternative allele |
|---|---|---|---|---|---|---|---|
| Periapical abscess | |||||||
| MAPT | NM_001123066.3 | Chr. 17 | 46028029 | rs7521 | A>G/A>C | East Asian | G = 0.786, C = 0.093 |
| CYP1A2 | NM_000761.5 | Chr. 15 | 74749576 | rs762551 | C>A | Other Asian | A = 0.73 |
| CYP4F2 | NM_001082.5 | Chr. 19 | 15879621 | rs2108622 | C>T | South Asian | T = 0.3638 |
| CYP2C9 | NM_000771.4 | Chr. 10 | 94981296 | rs1057910 | A>C | South Asian | C = 0.1147 |
| KAT2A | NM_001376227.1 | Chr. 17 | 42114374 | rs9303326 | A>G | African Others | G = 0.030 |
| HSD17B10 | NM_001037811.2 | Chr. X | 53432086 | rs28935475 | – | – | – |
| Radicular cyst | |||||||
| POLB | NM_002690.3 | Chr. 8 | 42361530 | rs2272615 | A>G | Other African | G = 0.831 |
| PRKAG2 | NM_001040633.1 | Chr. 7 | 151556140 | rs7429 | C>T | Other Asian | T = 0.79 |
| PRKAB2 | NM_005399.5 | Chr. 1 | 147155343 | rs6937 | T>C | East Asian | C = 0.6641 |
| F2 | NM_000506.5 | Chr. 11 | 46723453 | rs5896 | C>T | East Asian | T = 0.5986 |
| PRKAG3 | NM_017431.3 | Chr. 2 | 218831762 | rs60578863 | G>A | African Others | A = 0.090 |
| PRKAA2 | NM_006252.4 | Chr. 1 | 56706197 | rs17848599 | T>C | Other Asian | C = 0.06 |
| DPP4 | NM_001379604.1 | Chr. 2 | 162073412 | rs17575 | C>T | African Others | T = 0.053 |
| PRKAG1 | NM_001206709.2 | Chr. 12 | 49019703 | rs7975791 | C>T | European | T = 0.036586 |
| EHMT2 | NM_001289413.1 | Chr. 6 | 31883845 | rs61745377 | C>T | African Others | T = 0.033 |
| PRKAA1 | NM_001355028.2 | Chr. 5 | 40765115 | rs56138995 | T>C | South Asian | C = 0.01 |
| GSK3B | NM_001146156.2 | Chr. 3 | 119923394 | rs17183890 | C>T | African American | T = 0.0065 |
| PRKAB1 | NM_006253.5 | Chr. 12 | 119672396 | rs115821895 | G>A | Latin American 1 | A = 0.006 |
| Periapical granuloma | |||||||
| PPARD | NM_001171818.2 | Chr. 6 | 35428018 | rs9794 | G>C | Other African | C = 1.0 |
| TSHR | NM_000369.5 | Chr. 14 | 81144239 | rs1991517 | G>C | Other African | C = 0.943 |
| SLC16A1 | NM_001166496.1 | Chr. 1 | 112912477 | rs7169 | G>A | Other African | A = 0.907 |
| TERT | NM_001193376.2 | Chr. 5 | 1266195 | rs2075786 | A>G | European | G = 0.64999 |
| AR | NM_000044.6 | Chr. X | 67545785 | rs6152 | G>A | African Others | A = 0.631 |
| HCAR1 | NM_032554.4 | Chr. 12 | 122731922 | rs496911 | G>A | East Asian | A = 0.5804 |
| GPR84 | NM_020370.3 | Chr. 12 | 54365598 | rs2370872 | A>G | Latin American 1 | G = 0.541 |
| ESR1 | NM_000125.4 | Chr. 6 | 152122254 | rs12681 | C>T | African Others | T = 0.275 |
| NR0B1 | NM_000475.5 | Chr. X | 30309250 | rs6150 | G>A | European | A = 0.20578 |
| PPARA | NM_001001928.3 | Chr. 22 | 46218377 | rs1800206 | C>G | European | G = 0.06122 |
| SLC22A8 | NM_001184732.1 | Chr. 11 | 62993276 | rs11568487 | G>T | African Others | T = 0.028 |
| SLC22A6 | NM_004790.5 | Chr. 11 | 62977279 | rs11568635 | G>A | African American | A = 0.0120 |
| ESRRA | NM_001282450.1 | Chr. 11 | 64307271 | rs117285599 | C>T | Latin American 1 | T = 0.011 |
| RXRA | NM_001291920.1 | Chr. 9 | 134401726 | rs1805337 | C>T | Asian | T = 0.002 |
| PPARG | NM_001330615.4 | Chr. 3 | 12381349 | rs1800571 | – | – | – |