Table 5.

Causal network regulators between Phb1^+/− and WT.

Master regulator	Molecule type	Activation z-score	p-value of overlap	Target molecules in dataset
SREBF2	Transcription regulator	−3.16	2.07E-16	CYP51A1, FABP5, FDPS, IDI1, MSMO1, NSDHL, PCSK9, RDH11, SCD, SQLE
Arachidonic acid	Chemical - endogenous mammalian	2.31	2.16E-16	COL1A1, CYP51A1, FABP5, FDPS, IDI1, MSMO1, NSDHL, PCSK9, RDH11, SCD, SQLE, TIMP1
NR1H4	Ligand-dependent nuclear receptor	−1.73	9.98E-15	ACTA2, CYP51A1, FABP5, FDPS, FOXM1, IDI1, MSMO1, NSDHL, SCD, SQLE, SULT1E1, TIMP1
IGF1	Growth factor	−2.53	2.69E-14	ACTA2, COL1A1, CYP51A1, FDPS, IDI1, MSMO1, NSDHL, SCD, SQLE, TIMP1
SREBF1	Transcription regulator	−3.16	2.69E-14	CYP51A1, FABP5, FDPS, IDI1, MSMO1, NSDHL, PCSK9, RDH11, SCD, SQLE
SCAP	Other	−3	2.81E-14	CYP51A1, FDPS, IDI1, MSMO1, NSDHL, PCSK9, RDH11, SCD, SQLE
BTG1	Transcription regulator	−1.67	6.46E-14	ACTA2, COL1A1, CYP51A1, FDPS, IDI1, MSMO1, NSDHL, SCD, SQLE
PTPN1	Phosphatase	1.67	5.3E-13	COL1A1, CYP51A1, FDPS, IDI1, MSMO1, NSDHL, SCD, SQLE, TIMP1
INSR	Kinase	−2.65	7.27E-13	CYP51A1, FDPS, IDI1, MSMO1, NSDHL, SCD, SQLE
ATP7B	Transporter	−2.65	1.4E-11	Cyp2c40 (includes others), CYP51A1, FABP5, FDPS, IDI1, MSMO1, SQLE