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. 2021 Sep 3;13:725246. doi: 10.3389/fnagi.2021.725246

FIGURE 1.

FIGURE 1

Data analysis flowchart using fusion with reference. Extracted neuroimaging features (fALFF, GMV, and amyloid SUVR) are first stacked to 2D matrices for each modality. Then, PHS is used as the reference to guide the joint decomposition of three features to generate spatial maps (C1,C2,C3) and their corresponding canonical variants (A1,A2,A3). Finally, joint ICA is applied on the concatenated spatial maps to obtain the final ICs and their corresponding mixing matrices. fMRI, functional MRI; sMRI, structural MRI; HC, healthy control; MCI, mild cognitive impairment; AD, Alzheimer’s disease; fALFF, fractional amplitude of low frequency fluctuations; GMV, gray matter volume; SUVR, standard uptake value ratios; PHS, polygenic hazard score; MCCAR, multisite canonical correlation analysis with reference; ICA, independent component analysis; IC, independent components.