Fig. 1. The integrin family and targeted therapies.

All 24 distinct integrin heterodimers, formed from one α-subunit and one β-subunit, are represented and grouped according to their broad classification by cognate ligand or cellular expression. Therapeutically targeted integrins are highlighted in blue along with the therapeutic areas that are of current interest. Additionally, a select number of therapies in development, and marketed or terminated drugs and their modalities, are shown. Arrows are intended to demonstrate which integrin targets are thought to be key and their purpose is not to capture all known integrin activities. See Tables for additional information. ^aApproved for ulcerative colitis and Crohn’s disease. ^bBeing investigated clinically for ulcerative colitis. ^cAlso approved for Crohn’s disease in the USA.