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. 2021 Sep 17;21(1):60–78. doi: 10.1038/s41573-021-00284-4

Fig. 3. Selected small molecules with oral properties that bind to RGD integrins.

Fig. 3

The small molecules shown here have either been evaluated in the clinic or have been examined in preclinical models and are administered by a parenteral route with advantageous potency or selectivity profiles or are predicted to have these attributes based on their physicochemical properties. The molecules are: 13 MK-0429, 14 SB-273005, 15 PLN-74809 (proposed structure), 16 an example of the series from Bristol-Myers Squibb patent WO2019/094319, 17 an example of the series from St Louis University and Indalo Therapeutics patent WO2018/132268, 18 an example from GlaxoSmithKline’s patent WO2016/046226, 19 an example of the series from St Louis University patent WO2017/117538. RGD, Arg–Gly–Asp.