Table 2.

Study outcome comparison between the early and late awake prone group

Outcomes	Early Awake Prone (n = 92)	Late Awake Prone (n = 33)	P value
28 day mortality, n (%)	24 (26)	15 (45)	0.039
Death without intubation, n (%)	7 (7.6)	6 (18.2)	0.088
Hospital LOS (d), median (IQR)	13.97 (9.64–24.9)	12.53 (9–20.9)	0.66
ICU LOS (d), median (IQR)	7.91 (4.25–21)	8 (3.38–16.9)	0.55
IMV use, n (%)	34 (37)	14 (42.4)	0.58
IMV duration (d), median (IQR)	10.59 ± 6.12	8.89 ± 6.10	0.43
Time from HFNC start to intubation (d), median (IQR)	5.13 (1.89–10.85)	5.27 (3.2–9.56)	0.65
Time from APP start to intubation (d), median (IQR)	4.73 (1.85–10.6)	3.12 (1.31–8.23)	0.37
NIV use, n (%)	23 (25)	5 (15.2)	0.24
Time from HFNC start to NIV (d), median (IQR)	3.74 (0.83–9.61)	2.11 (0.7–8.95)	0.77
ECMO use, n (%)	2 (2.2)	0	0.54
Inhaled vasodilator use, n (%)	26 (28.3)	9 (27.3)	0.28

LOS length of stay, IQR interquartile range, ICU intensive care unit, IMV invasive mechanical ventilation, NIV noninvasive ventilation, HFNC high-flow nasal cannula, ECMO extracorporeal membrane oxygenation, APP Awake Prone Positioning