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. 2021 Sep 13;71:103571. doi: 10.1016/j.ebiom.2021.103571

FIGURE 3.

FIGURE 3

89Zr-Lumi804-αCD11b accumulation in glioma bearing mice is receptor mediated. Glioma-bearing mice received injection of 89Zr-Lumi804-αCD11b tracer alone or with 10x blocking dose (n=5/group). Mice were assessed at 72 h post-tracer injection. (a) Representative axial PET/CT images (n=2/group are shown). (b) Quantified SUVmean in tumour ipsilateral and contralateral hemisphere from both groups. (c) Biodistribution analysis of major organs. Data are represented as the mean ± SD; each data point represents a unique mouse. (Unpaired t-test was used to assess significance). (d) Biodistribution determined by ROI analysis (n=5) (e) Ratio of GL261 tumour accumulation to contralateral tissue.