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. 2021 Sep 13;71:103571. doi: 10.1016/j.ebiom.2021.103571

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

¹⁷⁷Lu-Lumi804-αCD11b TRT depletes CD11b⁺ cells in the immune-periphery and within the TME. Glioma-bearing mice were treated with αCD11b (control) or ¹⁷⁷Lu-Lumi804-α-CD11b TRT (either 14.8 MBq or 22.2 MBq). Spleen and tumour were harvested 5 days post-TRT, dissociated, and analysed by flow cytometry. (a) Myeloid cell populations, including MDSC, macrophages/TAM, and granulocytes, shown as a % of CD45⁺ leukocyte-gated cells in spleen, and (b) in tumour. (c) Lymphoid cell populations, including CTL and T_h, shown as a % of CD45⁺ lymphocyte-gated cells in spleen, and (d) in tumour. Data are represented as the mean ± SD. (One-way ANOVA with Tukey's multiple comparisons test was used to assess significance).