Fig. 8.

Unadjusted OS model of metastatic patients with known primary site of metastasis (n = 211) stratified based on study group per site of metastatic disease. Kaplan-Meier survival curves and log-rank test results of the different study groups with metastatic disease in the liver (n = 67) (A), bone (n = 65) (B), brain (n = 25) (C) and lungs (n = 45) (D). For brain metastasis, the observed difference in OS (P = 0.0075) among the different patient groups should be interpreted with caution as the PP-BC_DL patient group contained only one patient with brain metastasis.