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. 2021 Aug 17;38:100847. doi: 10.1016/j.gore.2021.100847

Fig. 2.

Fig. 2

Comparison between the size of recurrent tumors and allele frequencies of ctDNA. Panel A. The correlation of changes in tumor sizes and allele frequencies (AF). The vertical and horizontal axes indicate the changes in tumor sizes and allele frequencies in each case, respectively. The points of data acquisitions of each case were selected on the basis of the visible changes in metastatic legions in the CT images (see Panel B and C). The denominators and numerators were the data (tumor volume and AF) before and after the changes in metastatic lesion volumes, respectively. Panel B and C. Correlation of tumor volumes and AF after treatment of cases 1 (panel B: surgical resection) and 5 (panel: chemotherapy). In each panel, the top images are enhanced CT before and after the changes. The timings of imaging are indicated just below the images. Bottom graph indicates the changes in AFs (vertical axes) during time course (horizontal axes). Red arrows in the CT images indicate the recurrent tumors.