Table 2.
PHMT enzymes in humans and yeast
| Protein | Alt name | Organism | Specificity | Isomer | Function | Reference |
|---|---|---|---|---|---|---|
| SETD3 | C14orf154 | Hs | Actin–His73 | 3MeH | Actin polymerization, smooth muscle contractility | (9, 10) |
| METTL18 | ASTP2, C1orf156 | Hs | RPL3–His245 | 3MeH | Translation dynamics, pre-rRNA processing, polysome formation | (14) |
| METTL9 | DREV, CGI-81 | Hs | HxH, x = A, N, G, S, or T | 1MeH | Zn binding, respiration | (59, 60) |
| YIL110W | Hpm1 | Sc | Rpl3–His243 | 3MeH | rRNA processing, ribosome assembly | (52, 55) |
Abbreviations: Hs, Homo sapiens; Sc, Saccharomyces cerevisiae.