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Paneth cells of small intestine are found at the crypt base, intercalated among the active intestinal stem cells. Their close proximity allows them to interact with active intestinal stem cells in numerous ways. Illustrated here are interactions associated with Notch signaling, Wnt signaling, and provision of Paneth cell-derived lactate for use by active intestinal stem cells for oxidative phosphorylation. NAD+, oxidized nicotinamide adenine dinucleotide.
