Table 5.

Clinical efficacy search: MEDLINE^®/Embase^®

Search number	String	Results
S1	TI,AB (“acute myeloid leukemia” OR “acute myeloid leukaemia” OR “acute myelogenous leukemia” OR “acute myelogenous leukaemia” OR “acute myelocytic leukemia” OR “acute myelocytic leukaemia” OR “acute granulocytic leukemia” OR “acute granulocytic leukaemia” OR “acute non lymphocytic leukemia” OR “acute non-lymphocytic leukemia” OR “acute nonlymphocytic leukemia” OR “acute non lymphocytic leukaemia” OR “acute non-lymphocytic leukaemia” OR “acute nonlymphocytic leukaemia” OR “acute myeloblastic leukemia” OR “acute myeloblastic leukaemia” OR “AML”) OR EMB.EXPLODE (“acute myeloid leukemia”) OR MESH.EXPLODE (“Leukemia, Myeloid, Acute”)	187,761
S2	TI,AB (refractory OR relapse OR relapse* OR recurren* OR maintenance OR pretreated OR ((previously OR prior) NEAR/3 (treated OR treatment* OR therapy OR therapies))) OR EMB.EXACT (“refractory period”) OR EMB.EXACT (“relapse” OR “leukemia relapse”) OR MESH.EXACT (“Recurrence”)	2,954,678
S3	TI,AB (randomi* OR RCT OR placebo* OR “randomly allocated” OR (allocated NEAR/2 random*) OR (clinical NEAR/1 trial*) OR ((singl* OR doubl* OR treb* or tripl*) NEAR/1 (blind[*3] OR mask[*3]))) OR EMB.EXACT (“clinical trial” OR “randomized controlled trial” OR “controlled clinical trial” OR “multicenter study” OR “phase I clinical trial” OR “phase II clinical trial” OR “phase III clinical trial” OR “phase IV clinical trial” OR “single blind procedure” OR “double blind procedure” OR “crossover procedure” OR “placebo” OR “prospective study”) OR EMB.EXACT.EXPLODE (randomization) OR MESH.EXACT (“Randomized Controlled Trials as Topic” OR “Randomized Controlled Trial” OR “Random Allocation” OR “Double Blind Method” OR “Single Blind Method” OR “Clinical Trial” OR Placebos) OR MESH.EXACT.EXPLODE (“Clinical Trials as Topic”)	3,811,966
S4	TI,AB (“case report”) OR EMB.EXACT (“case study” OR “abstract report” OR letter) OR MESH.EXACT (Letter OR “Historical Article”)	1,969,041
S5	(S1 AND S2 AND S3) NOT S4	9903
S6	S5 AND LA (English) AND PD (>20071231) NOT (rtype.exact (“Conference Abstract”))	2361