Table 2. 68Ga-PSMA-11 Test Characteristics for the Composite 3 Blinded Reads and Overall Majority Rule Read.
Test characteristic | Read 1 | Read 2 | Read 3 | Majority read |
---|---|---|---|---|
True positive | 30 | 33 | 29 | 30 |
False positive | 13 | 16 | 15 | 10 |
True negative | 189 | 186 | 187 | 192 |
False negative | 45 | 42 | 46 | 45 |
Sensitivitya | 0.40 (0.30-0.51) | 0.44 (0.33-0.55) | 0.39 (0.28-0.50) | 0.40 (0.30-0.51) |
Specificitya | 0.94 (0.89-0.96) | 0.92 (0.88-0.95) | 0.93 (0.88-0.95) | 0.95 (0.91-0.97) |
PPVa | 0.70 (0.55-0.81) | 0.67 (0.53-0.79) | 0.66 (0.51-0.78) | 0.75 (0.60-0.86) |
NPVa | 0.81 (0.75-0.85) | 0.82 (0.76-0.86) | 0.80 (0.75-0.85) | 0.81 (0.76-0.85) |
Abbreviations: NPV, negative predictive value; PPV, positive predictive value; PSMA, prostate-specific membrane antigen.
95% CIs in parentheses.