Figure 2. Association Between Residual Cancer Burden (RCB) and Estimated Rate for Event-Free Survival (EFS) Event Within 3 Years for the Overall I-SPY2 Population, Each Phenotypic Subtype, and Each Category of Treatment After Adjustment for Phenotypic Subtype.

The estimated 3-year event rate was plotted on a log scale as a function of RCB index, using smoothing splines approximation from a Cox model. Shaded areas indicate 95% CIs. The cut points that define RCB classes are represented as vertical lines. HR indicates hormone receptor; pCR, pathologic complete response.