Table 5.

Linear regression analysis on the association between macrolide therapy and PTA_2–8 at follow-up

Use between both tinnitus assessments	Number	Model 1, difference [95% CI], P value	Model 2, difference [95% CI], P value
		n = 625	n = 605
No macrolide use	557	Ref.	Ref.
Macrolide use	68	–0.76 [–2.04; 0.51], P = 0.241	–0.76 [–2.08; 0.56], P = 0.260

Model 1 was adjusted for PTA_2–8 at baseline, age and sex.

Model 2 was additionally adjusted for SBP, alcohol (Last Observation Carried Forward), smoking, education level, BMI, diabetes, eGFR and other ototoxic drugs.