Fig. 5.

Knockout of ASC can effectively inhibit the development of SuHx-induced PH. (a, b) Bar charts showing right ventricle systolic pressure (RVSP) (a) and indices of RV weight (RV/LV+S) (b) in wild-type mice and ASC knockout mice, and all of the above groups stimulated with SU5416/hypoxia (n = 6). (c) Photomicrographs of serial sections of peripheral mice lung containing small arteries from the above groups of mice. Sections were immunostained for the α-SMA. Scale Bar = 50 µm. (d) Quantitative assessment of pulmonary arterial muscularization in the above groups. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA relative to SU5416/hypoxia.