TABLE A3.
AstraZeneca/Oxford supply chain
| Company | Location | Role | Key dates |
|---|---|---|---|
| Oxford University | Oxford, UK | Identifies COVID‐19 vaccine candidate | 18 March 2020 |
| AstraZeneca | Cambridge, UK | Develops, manufactures, and distributes Oxford vaccine | 30 April 2020 |
| Drug substance | |||
| Oxford Biomedica | Oxford, UK | Signs initial clinical and commercial supply agreements | 28 May 2020 |
| Serum Institute of India (SII) | Pune, India | Signs licensing agreement to supply 1 billion doses to poor countries, with commitment to provide 400 million before end of 2020 | 4 June 2020 |
| Emergent BioSolutions | Maryland, US |
Manufactures drug substance for clinical trials Manufactures drug substance at scale |
11 June 2020 27 July 2020 |
| Catalent | Maryland, US | Manufactures drug substance | 24 August 2020 |
| Cobra Biologics UK | Keele, UK | Manufactures drug substance | 16 June 2020 |
| NovaSep (Thermo Fisher) a | Seneffe, Belgium |
Manufactures drug substance Signs multiyear contract |
15 June 2020 |
| mAbxience | Garín, Argentina | Manufactures drug substance | 17 August 2020 |
| Halix | Leiden, Netherlands | Manufactures drug substance | 8 December 2020 |
| Siam Bioscience | Bangkok, Thailand | Manufactures drug substance for Thailand and Association of Southeast Asian Nation (ASEAN) countries | 12 October 2020 |
| IDT Biologika | Dessau, Germany | Signs letter of intent for joint investment and capacity to manufacture drug substance | 10 February 2021 |
| CSL | Broadmeadows, Australia |
Manufactures drug substance |
8 November 2020 |
| JCR Pharmaceuticals | Kobe, Japan |
Collaboration agreement Manufactures drug substance at new plant |
August, 2020 b March 2021 b |
| BioKangtai | Shenzhen, China | Manufactures drug substance, formulation, fill and finish for 100 million doses | 21 August 2020 |
| Fill and finish | |||
| Symbiosis Pharmaceutical | Scotland | Handles fill and finish for clinical trials | 22 June 2020 |
| AstraZeneca | Ohio, US | Handles fill and finish | 11 June 2020 c |
| CP Pharmaceuticals (Wockhardt) | Wrexham, Wales, UK | Handles fill and finish | 3 August 2020 |
| Catalent | Anagni, Italy | Handles fill and finish | 15 June 2020 |
| Fiocruz Institute | Rio de Janeiro, Brazil | Handles fill and finish, eventually manufactures drug product | 27 June 2020 |
| Laboratorios Liomont | Mexico | Handles fill and finish for Latin American (except Brazil) | 17 August 2020 |
| CSL | Parkville, Australia | Handles fill and finish | 8 November 2020 |
| KM Biologics b | Kumamoto prefecture, Japan | Handles fill and finish | 18 December 2020 |
| Daiichi Sankyo | Japan | Handles fill and finish | 5 February 2021 |
| Insud Pharma | Azuqueca de Henares, Guadalajara, Spain | Handles fill and finish | 20 January 2021 |
| IDT Biologika | Dessau, Germany | Handles fill and finish | 10 February 2021 |
a
Plant taken over by Thermo Fisher in January 2021.
b
Reported in FiercePharma.
c
Jacobs Engineering announces it is retrofitting the plant.
Source: Constructed by the authors. Hyperlinks provide original sources.